New insights into the effect of amorolfine nail lacquer. ( for Toenail Fungus )
Mycoses. 2005 Mar;48(2):91-4. Related Articles, Links
Flagothier C, Pierard-Franchimont C, Pierard GE.
Department of Dermatopathology, University Hospital of Liege, Liege, Belgium.
Despite improvements in antifungal strategies, the outcome of treating onychomycoses often remains uncertain. Several factors account for treatment failure, of which the pharmacokinetics and pharmacodynamics of the antifungal are of importance. The taxonomic nature and ungual location of the fungus cannot be neglected, besides the type of nail and its growth rate. In addition, the biological cycle of the fungus and the metabolic activity of the pathogen likely play a marked influence in drug response. The presence of natural antimicrobial peptides in the nail is also probably a key feature controlling the cure rates. There are many outstanding publications that cover the full spectrum of the field. The purpose of this review is to put in perspective some facets of activity of the topical treatment using amorolfine nail laquer. The antifungal activity of the drug is likely less pronounced in onychomycosis than that expected from conventional in vitro studies. However, the nail laquer formulation should reduce the propensity to form antifungal-resistant spores and limit the risk of reinfection.
Publication Types:
Review
Review, Tutorial
Reprinted with permission from PubMed online
Fungus Research L.L.C. recommends the potent, all natural formula Mycozil for the treatment of athlete's foot fungus, nail fungus, and toenail fungus. Mycozil is a powerful internal anti-fungal formula, which is highly effective against all fungal infections. The ingredients in Mycozil have been clinically proven against fungal infections. It is also highly effective against internal Candida or yeast infections. To read more about Mycozil or to place an order click here… |
